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血液系分化誘導法掲載論文一覧


Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. 2018, Stem Cells, PubMed ID: 29569827
A. Leung, E. Zulick, N. Skvir, K. Vanuytsel, T. A. Morrison, Z. H. Naing, Z. Wang, Y. Dai, D. H. K. Chui, M. H. Steinberg, D. H. Sherr and G. J. Murphy

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. 2018, Biochem Biophys Res Commun, 497, 719-725, PubMed ID: 29462620
K. Oshima, N. Saiki, M. Tanaka, H. Imamura, A. Niwa, A. Tanimura, A. Nagahashi, A. Hirayama, K. Okita, A. Hotta, S. Kitayama, M. Osawa, S. Kaneko, A. Watanabe, I. Asaka, W. Fujibuchi, K. Imai, H. Yabe, Y. Kamachi, J. Hara, S. Kojima, M. Tomita, T. Soga, T. Noma, S. Nonoyama, T. Nakahata and M. K. Saito

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1. 2018, Stem Cell Reports, 10, 447-460, PubMed ID: 29358086
H. Wang, C. Liu, X. Liu, M. Wang, D. Wu, J. Gao, P. Su, T. Nakahata, W. Zhou, Y. Xu, L. Shi, F. Ma and J. Zhou

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells. 2017, J Vis Exp, PubMed ID: 29155741
C. Dege and C. M. Sturgeon

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling. 2017, Stem Cells, 35, 2253-2266, PubMed ID: 28869683
O. Navarro-Montero, V. Ayllon, M. Lamolda, L. Lopez-Onieva, R. Montes, C. Bueno, E. Ng, X. Guerrero-Carreno, T. Romero, D. Romero-Moya, E. Stanley, A. Elefanty, V. Ramos-Mejia, P. Menendez and P. J. Real

Reprogramming technology reveals genetic and functional diversity of subclones in myelodysplastic syndromes. 2017, Rinsho Ketsueki, 58, 787-791, PubMed ID: 28781275
K. Chonabayashi, Y. Yoshida and A. Takaori-Kondo

Human haematopoietic stem cell development: from the embryo to the dish. 2017, Development, 144, 2323-2337, PubMed ID: 28676567
A. Ivanovs, S. Rybtsov, E. S. Ng, E. G. Stanley, A. G. Elefanty and A. Medvinsky

Hematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines Is Accompanied by the Morphology of Embryoid Bodies and the Expression of Endodermal and Hematopoietic Markers. 2017, Cell Reprogram, 19, 270-284, PubMed ID: 28632430
L. Tesarova, P. Simara, S. Stejskal and I. Koutna

Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells. 2017, Blood, 129, 3428-3439, PubMed ID: 28533309
M. G. Angelos, P. N. Ruh, B. R. Webber, R. H. Blum, C. D. Ryan, L. Bendzick, S. Shim, A. M. Yingst, D. M. Tufa, M. R. Verneris and D. S. Kaufman

Haematopoietic stem and progenitor cells from human pluripotent stem cells. 2017, Nature, 545, 432-438, PubMed ID: 28514439
R. Sugimura, D. K. Jha, A. Han, C. Soria-Valles, E. L. da Rocha, Y. F. Lu, J. A. Goettel, E. Serrao, R. G. Rowe, M. Malleshaiah, I. Wong, P. Sousa, T. N. Zhu, A. Ditadi, G. Keller, A. N. Engelman, S. B. Snapper, S. Doulatov and G. Q. Daley

Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4. 2017, Blood, 129, 2988-2992, PubMed ID: 28408465
J. P. Creamer, C. Dege, Q. Ren, J. T. K. Ho, M. C. Valentine, T. E. Druley and C. M. Sturgeon

Generation of hematopoietic stem cells from human embryonic stem cells using a defined, stepwise, serum-free, and serum replacement-free monolayer culture method. 2017, Blood Res, 52, 37-43, PubMed ID: 28401100
S. J. Kim, J. W. Jung, H. Y. Ha, S. K. Koo, E. G. Kim and J. H. Kim

Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring. 2017, Stem Cell Res, 20, 84-87, PubMed ID: 28395746
W. Wongkummool, W. Maneepitasut, T. Munkongdee, P. Tong-Ngam, A. Tangprasittipap, S. Svasti, N. Kitiyanant, K. Paiboonsukwong, S. Fucharoen and A. Tubsuwan

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts. 2017, Stem Cell Res, 18, 26-28, PubMed ID: 28395797
M. Hansen, E. Varga, T. Wust, N. Brouwer, H. Beauchemin, C. Mellink, A. M. van der Kevie-Kersemaekers, T. Moroy, B. van der Reijden, M. von Lindern and E. van den Akker

Establishment of MUi009 – A human induced pluripotent stem cells from a 32year old male with homozygous beta degrees -thalassemia coinherited with heterozygous alpha-thalassemia 2. 2017, Stem Cell Res, 20, 80-83, PubMed ID: 28395745
W. Wongkummool, W. Maneepitasut, P. Tong-Ngam, A. Tangprasittipap, T. Munkongdee, C. Boonchuay, S. Svasti, N. Kitiyanant, K. Paiboonsukwong, S. Fucharoen and A. Tubsuwan

Generating autologous hematopoietic cells from human-induced pluripotent stem cells through ectopic expression of transcription factors. 2017, Curr Opin Hematol, 24, 283-288, PubMed ID: 28383341
Y. Hwang, H. E. Broxmeyer and M. R. Lee

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. 2017, Stem Cell Res, 21, 32-39, PubMed ID: 28368243
X. Li, C. Xia, T. Wang, L. Liu, Q. Zhao, D. Yang, F. Hu, M. Zhang, K. Huang, Y. Geng, Y. Zheng, Y. Guan, H. Wu, X. Chen, G. Pan, J. Chen, J. Du and J. Wang

Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential. 2017, Stem Cell Res Ther, 8, 67, PubMed ID: 28302184
Y. Galat, S. Dambaeva, I. Elcheva, A. Khanolkar, K. Beaman, P. M. Iannaccone and V. Galat

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia. 2017, Cell Stem Cell, 20, 315-328.e7, PubMed ID: 28215825
A. G. Kotini, C. J. Chang, A. Chow, H. Yuan, T. C. Ho, T. Wang, S. Vora, A. Solovyov, C. Husser, M. Olszewska, J. Teruya-Feldstein, D. Perumal, V. M. Klimek, A. Spyridonidis, R. K. Rampal, L. Silverman, E. P. Reddy, E. Papaemmanuil, S. Parekh, B. D. Greenbaum, C. S. Leslie, M. G. Kharas and E. P. Papapetrou

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. 2017, Sci Transl Med, 9, PubMed ID: 28179501
S. Doulatov, L. T. Vo, E. R. Macari, L. Wahlster, M. A. Kinney, A. M. Taylor, J. Barragan, M. Gupta, K. McGrath, H. Y. Lee, J. M. Humphries, A. DeVine, A. Narla, B. P. Alter, A. H. Beggs, S. Agarwal, B. L. Ebert, H. T. Gazda, H. F. Lodish, C. A. Sieff, T. M. Schlaeger, L. I. Zon and G. Q. Daley

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages. 2017, Stem Cell Reports, 8, 334-345, PubMed ID: 28111278
J. Buchrieser, W. James and M. D. Moore

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. 2017, Cell Stem Cell, 20, 329-344.e7, PubMed ID: 28089908
M. P. Chao, A. J. Gentles, S. Chatterjee, F. Lan, A. Reinisch, M. R. Corces, S. Xavy, J. Shen, D. Haag, S. Chanda, R. Sinha, R. M. Morganti, T. Nishimura, M. Ameen, H. Wu, M. Wernig, J. C. Wu and R. Majeti

Induced pluripotent stem cell technology: A window for studying the pathogenesis of acquired aplastic anemia and possible applications. 2017, Exp Hematol, 49, 9-18, PubMed ID: 28062362
M. I. Elbadry, J. L. Espinoza and S. Nakao

A molecular roadmap of definitive erythropoiesis from human induced pluripotent stem cells. 2017, Br J Haematol, 176, 971-983, PubMed ID: 28060419
M. A. Razaq, S. Taylor, D. J. Roberts and L. Carpenter

Ten years of iPSC: clinical potential and advances in vitro hematopoietic differentiation. 2017, Cell Biol Toxicol, 33, 233-250, PubMed ID: 28039590
B. Paes, P. D. Moco, C. G. Pereira, G. S. Porto, E. M. de Sousa Russo, L. C. J. Reis, D. T. Covas and V. Picanco-Castro

Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells. 2017, Stem Cells, 35, 886-897, PubMed ID: 28026072
C. T. Yang, R. Ma, R. A. Axton, M. Jackson, A. H. Taylor, A. Fidanza, L. Marenah, J. Frayne, J. C. Mountford and L. M. Forrester

Efficient Generation of beta-Globin-Expressing Erythroid Cells Using Stromal Cell-Derived Induced Pluripotent Stem Cells from Patients with Sickle Cell Disease. 2017, Stem Cells, 35, 586-596, PubMed ID: 27739611
N. Uchida, J. J. Haro-Mora, A. Fujita, D. Y. Lee, T. Winkler, M. M. Hsieh and J. F. Tisdale

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro. 2017, Exp Hematol, 45, 85-93.e2, PubMed ID: 27693385
A. Giorgetti, J. Castano, C. Bueno, R. Diaz de la Guardia, M. Delgado, A. Bigas, L. Espinosa and P. Menendez

Biomarker Discovery by Modeling Behcet’s Disease with Patient-Specific Human Induced Pluripotent Stem Cells. 2017, Stem Cells Dev, 26, 133-145, PubMed ID: 27733093
M. Y. Son, Y. D. Kim, B. Seol, M. O. Lee, H. J. Na, B. Yoo, J. S. Chang and Y. S. Cho

Generation of an induced pluripotent stem cell line from a patient with chronic myeloid leukemia (CML) resistant to targeted therapies. 2016, Stem Cell Res, 17, 235-237, PubMed ID: 27879209
G. Telliam, O. Feraud, F. Griscelli, P. Opolon, D. Divers, A. Bennaceur-Griscelli and A. G. Turhan

Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T). 2016, Stem Cell Res, 17, 205-207, PubMed ID: 27879207
N. Bhatt, R. Ghosh, S. Roy, Y. Gao, M. Armanios, L. Cheng and S. Franco

Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells. 2016, PLoS One, 11, e0165949, PubMed ID: 27812199
A. Speidel, S. Felk, P. Reinhardt, J. Sterneckert and F. Gillardon

Progress towards generation of human haematopoietic stem cells. 2016, Nat Cell Biol, 18, 1111-1117, PubMed ID: 27723718
L. Wahlster and G. Q. Daley

Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors. 2016, BMC Genomics, 17, 817, PubMed ID: 27769165
A. T. Merryweather-Clarke, A. J. Tipping, A. A. Lamikanra, R. Fa, B. Abu-Jamous, H. P. Tsang, L. Carpenter, K. J. Robson, A. K. Nandi and D. J. Roberts

Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36. 2016, Stem Cell Reports, 7, 869-883, PubMed ID: 27720903
B. Mao, S. Huang, X. Lu, W. Sun, Y. Zhou, X. Pan, J. Yu, M. Lai, B. Chen, Q. Zhou, S. Mao, G. Bian, J. Zhou, T. Nakahata and F. Ma

A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges. 2016, Int J Hematol, 104, 647-660, PubMed ID: 27599982
Y. Sugimine, A. Niwa, H. Matsubara, K. Kobayashi, Y. Tabata, T. Heike, T. Nakahata and M. K. Saito

Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. 2016, Cell Biosci, 6, 50, PubMed ID: 27583127
H. R. Kim, J. H. Lee, H. R. Heo, S. R. Yang, K. S. Ha, W. S. Park, E. T. Han, H. Song and S. H. Hong

The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human beta-thalassemia in Mice. 2016, Sci Rep, 6, 32463, PubMed ID: 27581487
Z. Ou, X. Niu, W. He, Y. Chen, B. Song, Y. Xian, D. Fan, D. Tang and X. Sun

Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. 2016, Cell Stem Cell, 19, 341-54, PubMed ID: 27476965
M. Nishizawa, K. Chonabayashi, M. Nomura, A. Tanaka, M. Nakamura, A. Inagaki, M. Nishikawa, I. Takei, A. Oishi, K. Tanabe, M. Ohnuki, H. Yokota, M. Koyanagi-Aoi, K. Okita, A. Watanabe, A. Takaori-Kondo, S. Yamanaka and Y. Yoshida

High-Efficiency Serum-Free Feeder-Free Erythroid Differentiation of Human Pluripotent Stem Cells Using Small Molecules. 2016, Stem Cells Transl Med, 5, 1394-1405, PubMed ID: 27400796
E. N. Olivier, L. Marenah, A. McCahill, A. Condie, S. Cowan and J. C. Mountford

Concise Review: Recent Advances in the In Vitro Derivation of Blood Cell Populations. 2016, Stem Cells Transl Med, 5, 1330-1337, PubMed ID: 27388244
K. Batta, S. Menegatti, E. Garcia-Alegria, M. Florkowska, G. Lacaud and V. Kouskoff

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells. 2016, Stem Cells Transl Med, 5, 981-90, PubMed ID: 27352929
M. Jackson, R. Ma, A. H. Taylor, R. A. Axton, J. Easterbrook, M. Kydonaki, E. Olivier, L. Marenah, E. G. Stanley, A. G. Elefanty, J. C. Mountford and L. M. Forrester

Combining Single Strand Oligodeoxynucleotides and CRISPR/Cas9 to Correct Gene Mutations in beta-Thalassemia-induced Pluripotent Stem Cells. 2016, J Biol Chem, 291, 16576-85, PubMed ID: 27288406
X. Niu, W. He, B. Song, Z. Ou, D. Fan, Y. Chen, Y. Fan and X. Sun

Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage. 2016, Sci Rep, 6, 25917, PubMed ID: 27197878
E. Garcia-Alegria, M. Iluit, M. Stefanska, C. Silva, S. Heeg, S. J. Kimber, V. Kouskoff, G. Lacaud, A. Vijayaraghavan and K. Batta

Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease. 2016, Exp Mol Med, 48, e232, PubMed ID: 27174201
M. Y. Son, M. O. Lee, H. Jeon, B. Seol, J. H. Kim, J. S. Chang and Y. S. Cho

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities. 2016, Cell Rep, 15, 1228-41, PubMed ID: 27134169
K. Banno, S. Omori, K. Hirata, N. Nawa, N. Nakagawa, K. Nishimura, M. Ohtaka, M. Nakanishi, T. Sakuma, T. Yamamoto, T. Toki, E. Ito, T. Yamamoto, C. Kokubu, J. Takeda, H. Taniguchi, H. Arahori, K. Wada, Y. Kitabatake and K. Ozono

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. 2016, Nat Commun, 7, 11208, PubMed ID: 27052461
T. Moreau, A. L. Evans, L. Vasquez, M. R. Tijssen, Y. Yan, M. W. Trotter, D. Howard, M. Colzani, M. Arumugam, W. H. Wu, A. Dalby, R. Lampela, G. Bouet, C. M. Hobbs, D. C. Pask, H. Payne, T. Ponomaryov, A. Brill, N. Soranzo, W. H. Ouwehand, R. A. Pedersen and C. Ghevaert

In Vitro Generation of Antigen-Specific T Cells from Induced Pluripotent Stem Cells of Antigen-Specific T Cell Origin. 2016, Methods Mol Biol, 1393, 67-73, PubMed ID: 27033216
S. Kaneko

Concise review: programming human pluripotent stem cells into blood. 2016, Br J Haematol, 173, 671-9, PubMed ID: 26996518
J. Easterbrook, A. Fidanza and L. M. Forrester

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. 2016, PLoS One, 11, e0149291, PubMed ID: 26938212
O. Feraud, Y. Valogne, M. W. Melkus, Y. Zhang, N. Oudrhiri, R. Haddad, A. Daury, C. Rocher, A. Larbi, P. Duquesnoy, D. Divers, E. Gobbo, P. Brunet de la Grange, F. Louache, A. Bennaceur-Griscelli and M. T. Mitjavila-Garcia

Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. 2016, Stem Cells, 34, 1239-50, PubMed ID: 26934332
C. J. Chin, A. R. Cooper, G. R. Lill, D. Evseenko, Y. Zhu, C. B. He, D. Casero, M. Pellegrini, D. B. Kohn and G. M. Crooks

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis. 2016, Stem Cells, 34, 1513-26, PubMed ID: 26866427
C. L. Sweeney, R. Teng, H. Wang, R. K. Merling, J. Lee, U. Choi, S. Koontz, D. G. Wright and H. L. Malech

beta-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs. 2016, Stem Cells, 34, 1541-52, PubMed ID: 26866725
A. Fujita, N. Uchida, J. J. Haro-Mora, T. Winkler and J. Tisdale

Valproic Acid Enhances iPSC Induction From Human Bone Marrow-Derived Cells Through the Suppression of Reprogramming-Induced Senescence. 2016, J Cell Physiol, 231, 1719-27, PubMed ID: 26620855
X. Chen, Y. Zhai, D. Yu, J. Cui, J. F. Hu and W. Li

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. 2016, Cell Stem Cell, 18, 73-78, PubMed ID: 26607381
F. C. Giani, C. Fiorini, A. Wakabayashi, L. S. Ludwig, R. M. Salem, C. D. Jobaliya, S. N. Regan, J. C. Ulirsch, G. Liang, O. Steinberg-Shemer, M. H. Guo, T. Esko, W. Tong, C. Brugnara, J. N. Hirschhorn, M. J. Weiss, L. I. Zon, S. T. Chou, D. L. French, K. Musunuru and V. G. Sankaran

Making a Hematopoietic Stem Cell. 2016, Trends Cell Biol, 26, 202-214, PubMed ID: 26526106
M. G. Daniel, C. F. Pereira, I. R. Lemischka and K. A. Moore

GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. 2016, Exp Hematol, 44, 68-74.e1-10, PubMed ID: 26477526
K. Kitajima, M. Nakajima, M. Kanokoda, M. Kyba, A. Dandapat, J. Tolar, M. K. Saito, M. Toyoda, A. Umezawa and T. Hara

Directed differentiation of definitive hemogenic endothelium and hematopoietic progenitors from human pluripotent stem cells. 2016, Methods, 101, 65-72, PubMed ID: 26439174
A. Ditadi and C. M. Sturgeon

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells. 2016, J Cell Physiol, 231, 1065-76, PubMed ID: 26395760
H. Bai, Y. Liu, Y. Xie, D. L. Hoyle, R. A. Brodsky, L. Cheng, T. Cheng and Z. Z. Wang

Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation. 2016, Stem Cells, 34, 797-9, PubMed ID: 26388310
D. Hoffmann, G. Gohring, M. Heuser, A. Ganser, A. Schambach and M. A. Morgan

In Vitro Differentiation of Embryonic Stem Cells into Hematopoietic Lineage: Towards Erythroid Progenitor’s Production. 2016, Methods Mol Biol, 1341, 217-34, PubMed ID: 26160454
I. Fauzi, N. Panoskaltsis and A. Mantalaris

Selective Differentiation into Hematopoietic and Cardiac Cells from Pluripotent Stem Cells Based on the Expression of Cell Surface Markers. 2016, Methods Mol Biol, 1341, 181-95, PubMed ID: 26138986
A. Okada, K. Tashiro, T. Yamaguchi and K. Kawabata

Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells. 2016, Methods Mol Biol, 1357, 295-310, PubMed ID: 25697415
A. Yanagida, H. Nakauchi and A. Kamiya

Generation of Megakaryocytes and Platelets from Human Pluripotent Stem Cells. 2016, Methods Mol Biol, 1307, 371-8, PubMed ID: 24297316
M. Pick

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells. 2015, J Vis Exp, e52910, PubMed ID: 26710184
I. Elcheva, V. Brok-Volchanskaya and I. Slukvin

On signaling pathways: hematopoietic stem cell specification from hemogenic endothelium. 2015, Sci China Life Sci, 58, 1256-61, PubMed ID: 26612042
Y. Long and H. Huang

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. 2015, Stem Cell Res, 15, 395-402, PubMed ID: 26339946
X. Chen, Q. Zhao, C. Li, Y. Geng, K. Huang, J. Zhang, X. Wang, J. Yang, T. Wang, C. Xia, X. Liu, M. Meng, D. Yang, Y. Zheng, J. Du, X. Zhang, J. Chen, G. Pan and J. Wang

OP9 Stromal Cells Proteins Involved in Hematoendothelial Differentiation from Human Embryonic Stem Cells. 2015, Cell Reprogram, 17, 338-46, PubMed ID: 26295456
L. M. Figueiredo, E. B. Costa, M. D. Orellana, V. Picanco-Castro and D. T. Covas

TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells. 2015, Biomaterials, 69, 191-200, PubMed ID: 26295532
A. K. Dreyer, D. Hoffmann, N. Lachmann, M. Ackermann, D. Steinemann, B. Timm, U. Siler, J. Reichenbach, M. Grez, T. Moritz, A. Schambach and T. Cathomen

In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination. 2015, Stem Cells, 33, 3174-80, PubMed ID: 26227158
M. J. Smith, B. R. Webber, M. Mohtashami, H. E. Stefanski, J. C. Zuniga-Pflucker and B. R. Blazar

Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells. 2015, Exp Hematol, 43, 756-9, PubMed ID: 26143581
S. Singbrant, P. van Galen, D. Lucas, G. Challen, D. J. Rossi and G. Q. Daley

Improved hematopoietic differentiation of primate embryonic stem cells by inhibition of the PI3K-AKT pathway under defined conditions. 2015, Exp Hematol, 43, 901-911.e4, PubMed ID: 26073521
T. Nii, T. Marumoto, H. Kohara, S. Yamaguchi, H. Kawano, E. Sasaki, Y. Kametani and K. Tani

Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. 2015, Curr Opin Hematol, 22, 317-23, PubMed ID: 26049752
J. Lee, B. Dykstra, R. Sackstein and D. J. Rossi

Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. 2015, Sci Rep, 5, 9882, PubMed ID: 26044259
M. Su, R. Hu, J. Jin, Y. Yan, Y. Song, R. Sullivan and L. Lai

Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis. 2015, Exp Hematol, 43, 849-57, PubMed ID: 26021490
H. Iizuka, Y. Kagoya, K. Kataoka, A. Yoshimi, M. Miyauchi, K. Taoka, K. Kumano, T. Yamamoto, A. Hotta, S. Arai and M. Kurokawa

Cooperative Effect of Erythropoietin and TGF-beta Inhibition on Erythroid Development in Human Pluripotent Stem Cells. 2015, J Cell Biochem, 116, 2735-43, PubMed ID: 26012423
Y. Xie, H. Bai, Y. Liu, D. L. Hoyle, T. Cheng and Z. Z. Wang

Embryonic stem cells as sources of donor-independent platelets. 2015, J Clin Invest, 125, 2261-3, PubMed ID: 25961451
M. C. Canver, D. E. Bauer and S. H. Orkin

Molecular signature of erythroblast enucleation in human embryonic stem cells. 2015, Stem Cells, 33, 2431-41, PubMed ID: 25850942
S. Rouzbeh, L. Kobari, M. Cambot, C. Mazurier, N. Hebert, A. M. Faussat, C. Durand, L. Douay and H. Lapillonne

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells. 2015, Nat Biotechnol, 33, 646-55, PubMed ID: 25798938
A. G. Kotini, C. J. Chang, I. Boussaad, J. J. Delrow, E. K. Dolezal, A. B. Nagulapally, F. Perna, G. A. Fishbein, V. M. Klimek, R. D. Hawkins, D. Huangfu, C. E. Murry, T. Graubert, S. D. Nimer and E. P. Papapetrou

Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations. 2015, Stem Cells, 33, 1839-49, PubMed ID: 25764124
K. R. Salci, J. H. Lee, S. Laronde, S. Dingwall, R. Kushwah, A. Fiebig-Comyn, B. Leber, R. Foley, A. Dal Cin and M. Bhatia

Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors. 2015, Stem Cells Transl Med, 4, 333-8, PubMed ID: 25762002
N. M. Suzuki, A. Niwa, M. Yabe, A. Hira, C. Okada, N. Amano, A. Watanabe, K. Watanabe, T. Heike, M. Takata, T. Nakahata and M. K. Saito

The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. 2015, Stem Cell Reports, 4, 658-69, PubMed ID: 25754204
F. Perna, L. P. Vu, M. Themeli, S. Kriks, R. Hoya-Arias, R. Khanin, T. Hricik, J. Mansilla-Soto, E. P. Papapetrou, R. L. Levine, L. Studer, M. Sadelain and S. D. Nimer

Development of hematopoietic stem and progenitor cells from human pluripotent stem cells. 2015, J Cell Biochem, 116, 1179-89, PubMed ID: 25740540
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Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents. 2015, Stem Cells Transl Med, 4, 309-19, PubMed ID: 25713465
Y. Liu, Y. Wang, Y. Gao, J. A. Forbes, R. Qayyum, L. Becker, L. Cheng and Z. Z. Wang

Transcription factor-mediated reprogramming toward hematopoietic stem cells. 2015, Embo j, 34, 694-709, PubMed ID: 25712209
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Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. 2015, Stem Cell Reports, 4, 282-96, PubMed ID: 25680479
N. Lachmann, M. Ackermann, E. Frenzel, S. Liebhaber, S. Brennig, C. Happle, D. Hoffmann, O. Klimenkova, D. Luttge, T. Buchegger, M. P. Kuhnel, A. Schambach, S. Janciauskiene, C. Figueiredo, G. Hansen, J. Skokowa and T. Moritz

Retinoic acid regulates hematopoietic development from human pluripotent stem cells. 2015, Stem Cell Reports, 4, 269-81, PubMed ID: 25680478
R. E. Ronn, C. Guibentif, R. Moraghebi, P. Chaves, S. Saxena, B. Garcia and N. B. Woods

Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells. 2015, Cytotherapy, 17, 344-58, PubMed ID: 25680303
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The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells. 2015, Stem Cells, 33, 1130-41, PubMed ID: 25546363
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Human induced pluripotent stem cell-derived B lymphocytes express sIgM and can be generated via a hemogenic endothelium intermediate. 2015, Stem Cells Dev, 24, 1082-95, PubMed ID: 25519920
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Wiskott-Aldrich syndrome iPS cells produce megakaryocytes with defects in cytoskeletal rearrangement and proplatelet formation. 2015, Thromb Haemost, 113, 792-805, PubMed ID: 25518736
P. Ingrungruanglert, P. Amarinthnukrowh, R. Rungsiwiwut, S. Maneesri-le Grand, D. Sosothikul, K. Suphapeetiporn, N. Israsena and V. Shotelersuk

Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. 2015, Stem Cells Dev, 24, 1053-65, PubMed ID: 25517294
B. Song, Y. Fan, W. He, D. Zhu, X. Niu, D. Wang, Z. Ou, M. Luo and X. Sun

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis. 2015, Haematologica, 100, 157-66, PubMed ID: 25381126
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Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin. 2015, Haematologica, 100, 32-41, PubMed ID: 25326431
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SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. 2015, Mol Ther, 23, 158-70, PubMed ID: 25292191
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An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease. 2015, Mol Ther, 23, 147-57, PubMed ID: 25288370
R. K. Merling, C. L. Sweeney, J. Chu, A. Bodansky, U. Choi, D. L. Priel, D. B. Kuhns, H. Wang, S. Vasilevsky, S. S. De Ravin, T. Winkler, C. E. Dunbar, J. Zou, K. A. Zarember, J. I. Gallin, S. M. Holland and H. L. Malech

Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia. 2014, Biochem Biophys Res Commun, 454, 102-8, PubMed ID: 25450364
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Scalable generation of universal platelets from human induced pluripotent stem cells. 2014, Stem Cell Reports, 3, 817-31, PubMed ID: 25418726
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Generation of human beta-thalassemia induced pluripotent cell lines by reprogramming of bone marrow-derived mesenchymal stromal cells using modified mRNA. 2014, Cell Reprogram, 16, 447-55, PubMed ID: 25354259
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HOXA9 promotes hematopoietic commitment of human embryonic stem cells. 2014, Blood, 124, 3065-75, PubMed ID: 25185710
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Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. 2014, Science, 345, 1247391, PubMed ID: 25146295
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Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects. 2014, Blood, 124, 1926-30, PubMed ID: 25114263
J. P. Connelly, E. M. Kwon, Y. Gao, N. S. Trivedi, A. G. Elkahloun, M. S. Horwitz, L. Cheng and P. P. Liu

Induction of adult levels of beta-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL. 2014, Haematologica, 99, 1677-85, PubMed ID: 25107887
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Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. 2014, Genome Res, 24, 1526-33, PubMed ID: 25096406
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Hematopoietic differentiation of pluripotent stem cells in culture. 2014, Methods Mol Biol, 1185, 181-94, PubMed ID: 25062629
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Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. 2014, Nat Commun, 5, 4330, PubMed ID: 24999918
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Bottlenecks in deriving definitive hematopoietic stem cells from human pluripotent stem cells: a CIRM mini-symposium and workshop report. 2014, Stem Cells Transl Med, 3, 775-81, PubMed ID: 24973044
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Generation of multipotent early lymphoid progenitors from human embryonic stem cells. 2014, Stem Cells Dev, 23, 2983-95, PubMed ID: 24955741
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Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells. 2014, Proc Natl Acad Sci U S A, 111, 8889-94, PubMed ID: 24889605
K. Felgentreff, L. Du, K. G. Weinacht, K. Dobbs, M. Bartish, S. Giliani, T. Schlaeger, A. DeVine, A. Schambach, L. J. Woodbine, G. Davies, S. N. Baxi, M. van der Burg, J. Bleesing, A. Gennery, J. Manis, Q. Pan-Hammarstrom and L. D. Notarangelo

Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells. 2014, Stem Cells Transl Med, 3, 792-800, PubMed ID: 24873860
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Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. 2014, Nat Biotechnol, 32, 554-61, PubMed ID: 24837661
C. M. Sturgeon, A. Ditadi, G. Awong, M. Kennedy and G. Keller

Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. 2014, Br J Haematol, 166, 435-48, PubMed ID: 24837254
C. T. Yang, A. French, P. A. Goh, A. Pagnamenta, S. Mettananda, J. Taylor, S. Knight, A. Nathwani, D. J. Roberts, S. M. Watt and L. Carpenter

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients. 2014, Leukemia, 28, 2344-54, PubMed ID: 24732596
M. Sakurai, H. Kunimoto, N. Watanabe, Y. Fukuchi, S. Yuasa, S. Yamazaki, T. Nishimura, K. Sadahira, K. Fukuda, H. Okano, H. Nakauchi, Y. Morita, I. Matsumura, K. Kudo, E. Ito, Y. Ebihara, K. Tsuji, Y. Harada, H. Harada, S. Okamoto and H. Nakajima

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells. 2014, Stem Cells, 32, 2084-97, PubMed ID: 24723429
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MicroRNAs in hematopoietic development. 2014, BMC Immunol, 15, 14, PubMed ID: 24678908
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Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. 2014, Stem Cells, 32, 1503-14, PubMed ID: 24677652
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Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells. 2014, Cell Stem Cell, 14, 535-48, PubMed ID: 24529595
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Ex vivo production of platelets from stem cells. 2014, Br J Haematol, 165, 237-47, PubMed ID: 24521452
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Role of BRD4 in hematopoietic differentiation of embryonic stem cells. 2014, Epigenetics, 9, 566-78, PubMed ID: 24445267
R. M. Rodriguez, B. Suarez-Alvarez, R. Salvanes, C. Huidobro, E. G. Torano, J. L. Garcia-Perez, C. Lopez-Larrea, A. F. Fernandez, C. Bueno, P. Menendez and M. F. Fraga

The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells. 2014, Stem Cell Res, 12, 441-51, PubMed ID: 24412757
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Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. 2014, J Invest Dermatol, 134, 1246-1254, PubMed ID: 24317394
J. Tolar, J. A. McGrath, L. Xia, M. J. Riddle, C. J. Lees, C. Eide, D. R. Keene, L. Liu, M. J. Osborn, T. C. Lund, B. R. Blazar and J. E. Wagner

Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells. 2014, Stem Cells, 32, 269-78, PubMed ID: 24105986
Z. Ye, C. F. Liu, L. Lanikova, S. N. Dowey, C. He, X. Huang, R. A. Brodsky, J. L. Spivak, J. T. Prchal and L. Cheng

Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. 2014, Haematologica, 99, 19-27, PubMed ID: 23975175
T. Morishima, K. Watanabe, A. Niwa, H. Hirai, S. Saida, T. Tanaka, I. Kato, K. Umeda, H. Hiramatsu, M. K. Saito, K. Matsubara, S. Adachi, M. Kobayashi, T. Nakahata and T. Heike

Driven hematopoietic differentiation of embryonic stem cells: epigenetic perspectives. 2014, Curr Pharm Des, 20, 1674-86, PubMed ID: 23888965
L. Tesarova, S. Stejskal and I. Koutna

MicroRNA-20b and ERK1/2 pathway independently regulate the expression of tissue factor in hematopoietic and trophoblastic differentiation of human embryonic stem cells. 2013, Stem Cell Res Ther, 4, 121, PubMed ID: 24405935
Y. H. Yu, D. S. Wu, F. F. Huang, Z. Zhang, L. X. Liu, J. Zhang, H. E. Zhan, M. Y. Peng, H. Zeng and F. P. Chen

Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free beta-thalassemia induced pluripotent stem cells. 2013, J Biol Chem, 288, 34671-9, PubMed ID: 24155235
N. Ma, B. Liao, H. Zhang, L. Wang, Y. Shan, Y. Xue, K. Huang, S. Chen, X. Zhou, Y. Chen, D. Pei and G. Pan

Transcriptome dynamics during human erythroid differentiation and development. 2013, Genomics, 102, 431-441, PubMed ID: 24121002
Y. Yang, H. Wang, K. H. Chang, H. Qu, Z. Zhang, Q. Xiong, H. Qi, P. Cui, Q. Lin, X. Ruan, Y. Yang, Y. Li, C. Shu, Q. Li, E. K. Wakeland, J. Yan, S. Hu and X. Fang

Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cells. 2013, Stem Cells Transl Med, 2, 819-29, PubMed ID: 24113066
X. Yuan, E. M. Braunstein, Z. Ye, C. F. Liu, G. Chen, J. Zou, L. Cheng and R. A. Brodsky

Erythro-myeloid progenitors: “definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells. 2013, Blood Cells Mol Dis, 51, 220-5, PubMed ID: 24095199
J. M. Frame, K. E. McGrath and J. Palis

Variable behavior of iPSCs derived from CML patients for response to TKI and hematopoietic differentiation. 2013, PLoS One, 8, e71596, PubMed ID: 24058405
A. Bedel, J. M. Pasquet, E. Lippert, M. Taillepierre, V. Lagarde, S. Dabernat, P. Dubus, L. Charaf, F. Beliveau, H. de Verneuil, E. Richard, F. X. Mahon and F. Moreau-Gaudry

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions. 2013, PLoS One, 8, e71098, PubMed ID: 23951090
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Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. 2013, Blood, 122, 2047-51, PubMed ID: 23940280
J. A. Mills, K. Wang, P. Paluru, L. Ying, L. Lu, A. M. Galvao, D. Xu, Y. Yao, S. K. Sullivan, L. M. Sullivan, H. Mac, A. Omari, J. C. Jean, S. Shen, A. Gower, A. Spira, G. Mostoslavsky, D. N. Kotton, D. L. French, M. J. Weiss and P. Gadue

Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. 2013, Stem Cells Transl Med, 2, 558-66, PubMed ID: 23847002
L. Ye, M. O. Muench, N. Fusaki, A. I. Beyer, J. Wang, Z. Qi, J. Yu and Y. W. Kan

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. 2013, Stem Cell Res Ther, 4, 71, PubMed ID: 23796405
W. F. Lim, T. Inoue-Yokoo, K. S. Tan, M. I. Lai and D. Sugiyama

The balance of positive and negative effects of TGF-beta signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells. 2013, Stem Cells Dev, 22, 2765-76, PubMed ID: 23758278
H. Bai, Y. L. Xie, Y. X. Gao, T. Cheng and Z. Z. Wang

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients. 2013, Blood, 122, 912-21, PubMed ID: 23744582
L. Garcon, J. Ge, S. H. Manjunath, J. A. Mills, M. Apicella, S. Parikh, L. M. Sullivan, G. M. Podsakoff, P. Gadue, D. L. French, P. J. Mason, M. Bessler and M. J. Weiss

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells. 2013, Blood, 122, 1162-73, PubMed ID: 23733337
J. B. Lee, T. E. Werbowetski-Ogilvie, J. H. Lee, B. A. McIntyre, A. Schnerch, S. H. Hong, I. H. Park, G. Q. Daley, I. D. Bernstein and M. Bhatia

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted beta-thalassemia patient. 2013, Stem Cells, 31, 1785-94, PubMed ID: 23712774
A. Tubsuwan, S. Abed, A. Deichmann, M. D. Kardel, C. Bartholoma, A. Cheung, O. Negre, Z. Kadri, S. Fucharoen, C. von Kalle, E. Payen, S. Chretien, M. Schmidt, C. J. Eaves, P. Leboulch and L. Maouche-Chretien

Defining the path to hematopoietic stem cells. 2013, Nat Biotechnol, 31, 416-8, PubMed ID: 23657396
C. M. Sturgeon, A. Ditadi, R. L. Clarke and G. Keller

Development of patient-specific hematopoietic stem and progenitor cell grafts from pluripotent stem cells, in vitro. 2013, Curr Mol Med, 13, 815-20, PubMed ID: 23642062
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Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. 2013, Blood, 121, 4925-9, PubMed ID: 23620576
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Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. 2013, Cell Stem Cell, 12, 727-36, PubMed ID: 23602541
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Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. 2013, J Clin Invest, 123, 1952-63, PubMed ID: 23585473
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FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs. 2013, Blood, 121, 3867-78, s1-3, PubMed ID: 23479570
C. Bueno, V. Ayllon, R. Montes, O. Navarro-Montero, V. Ramos-Mejia, P. J. Real, D. Romero-Moya, M. J. Arauzo-Bravo and P. Menendez

Generation of functional platelets from canine induced pluripotent stem cells. 2013, Stem Cells Dev, 22, 2026-35, PubMed ID: 23409943
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RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. 2013, Blood, 121, 2882-90, PubMed ID: 23372166
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Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors. 2013, Stem Cells, 31, 1022-9, PubMed ID: 23280624
S. K. Yung, K. Tilgner, M. H. Ledran, S. Habibollah, I. Neganova, C. Singhapol, G. Saretzki, M. Stojkovic, L. Armstrong, S. Przyborski and M. Lako

Mesodermal and hematopoietic differentiation from ES and iPS cells. 2013, Stem Cell Rev, 9, 422-34, PubMed ID: 22684542
T. Inoue-Yokoo, K. Tani and D. Sugiyama