2016年のノーベル医学・生理学賞は、「オートファジーの仕組みの解明」で大隅良典先生（東京工業大学栄誉教授）が受賞されました[1]。
理研BRCには水島昇先生（東京大学大学院教授）ならびに小松雅明先生（新潟大学大学院教授）が大隅良典先生との共著[2, 3]によりご発表されたオートファジー研究に有用な細胞株が寄託されています。
皆様のご利用をお待ちいたしております。
保有リソースリスト
| 細胞番号 | 細胞名 | 寄託者 | 文献 | 利用者文献 |
|---|---|---|---|---|
| RCB2710 | Atg5^(+/+)MEF | 水島昇先生 | ||
| RCB2711 | Atg5^(-/-)MEF | 水島昇先生 | ||
| RCB3706 | Atg7 +/+ MEFs | 小松雅明先生 | ||
| RCB3707 | Atg7 -/- MEFs | 小松雅明先生 | ||
| RCB3708 | Atg3 +/+ MEFs | 小松雅明先生 | ||
| RCB3709 | Atg3 -/- MEFs | 小松雅明先生 |
文献
[1]The 2016 Nobel Prize in Physiology or Medicine
[2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004. PMID: 15525940
[3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005. PMID: 15866887
利用者文献
| Title | PubMedID |
|---|---|
| Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection. | 25091564 |
| Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation. | 24130786 |
| Delphinidin Induces Autolysosome as well as Autophagosome Formation and Delphinidin-Induced Autophagy Exerts a Cell Protective Role. | 23129091 |
| H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition. | 23810683 |
| Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus. | 23006589 |
| Sucrose induces vesicle accumulation and autophagy. | 25389129 |
| Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. | 25179110 |
| Induction of Interferon-Stimulated Genes by Chlamydia pneumoniae in Fibroblasts Is Mediated by Intracellular Nucleotide-Sensing Receptors. | 20386592 |
| Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. | 22982048 |
| Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation. | 21289194 |
| Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein. | 26957541 |
| Autophagosomal IB Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor–induced Nuclear Factor-B (NF-B)Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity. | |
| Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.(NF-κB) Activity. | 21454695 |
| Plasma cells require autophagy for sustainable immunoglobulin production. | 23354484 |
| A novel quantitative flow cytometry-based assay for autophagy. | 20458170 |
| Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins. | 22438538 |
| A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. | 21368103 |
| Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. | 21536669 |
| Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1. | 21536669 |
| Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α. | 24648524 |
| Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells. | 23452544 |
| Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates.Renal Ischemia-Reperfusion Injury | 26444017 |
その他理研BRCが保有するオートファジー関連リソース
