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Human ES cells

Please read carefully the Japanese governmental guidelines on the utilization of human embryonic stem (ES) cells .
The guidelines stipulate requirements for distribution of human ES cells from Japan to foreign countries.

In order to be in compliance with the Japanese governmental guidelines, the following procedures are required:

(a) The RECIPIENT submits all of the following documents to the RIKEN BRC:
1. Initial Order Form
2. A copy of the written approval from the RECIPIENT’s institutional review board (IRB) or institutional ethical committee (IEC)
3. Japanese translation of the above written approval
4. A copy of the regulations in the RECIPIENT’s institution for the use of human ES cells. Please highlight the sections or sentences that stipulate the IRB or IEC is in compliance with the applicable laws and/or guidelines. The regulations written in English are acceptable. If the regulations are written in a language other than English or Japanese, please submit English or Japanese translation of the relevant sections or sentences.

(b) The RIKEN BRC obtains a permission from the DEPOSITOR for the distribution. Some DEPOSITORs may request conclusion of an additional MTA between the RECIPIENT and the DEPOSITOR.

(c) After obtaining the permission of the DEPOSITOR, the RIKEN BRC consults its IEC for appropriateness of the distribution based on the documents submitted by the RECIPIENT.

(d) After obtaining the approval of its IEC, the RIKEN BRC submits the documents to the Minister of Education, Culture, Sports, Science and Technology of Japan for his/her confirmation of the distribution.

(e) After receiving the confirmation by the Minister, the RIKEN BRC concludes the MTA with the RECIPIENT. Several articles in the MTA are stipulated to be in compliance with the Japanese governmental guidelines.

If you have any queries, please e-mail to the following address.
cellbankbrc.riken.jp


Deposited human ES cell lines are below.

KhES-1 (HES0001)
KhES-2 (HES0002)
KhES-3 (HES0003)
KhES-4 (HES0004)
KhES-5 (HES0005)
SEES1 (HES0006)
SEES2 (HES0007)
SEES3 (HES0008)


1V-90597-4A (HES0009) : Subline of SEES3 expressing human CDX2
1V-90597-2B (HES0010) : Subline of SEES3 expressing human CDX2
1V-90930-1A (HES0011) : Subline of SEES3 expressing human ESRRB
1V-90930-3B (HES0012) : Subline of SEES3 expressing human ESRRB
1V-91688-4A (HES0013) : Subline of SEES3 expressing human EOMES
1V-91688-2B (HES0014) : Subline of SEES3 expressing human EOMES
1V-90551-6A (HES0015) : Subline of SEES3 expressing human ELF5
1V-90551-1B (HES0016) : Subline of SEES3 expressing human ELF5