Research tools to investigate the role of autophagy in the cell lines

(Last Update:2016.10.6)

The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular cells to investigate the role of autophagy in the cell lines. [2,3].

List of cell lines

Cell No. Cell Name Depositor References
RCB2710 Atg5^(+/+)MEF Dr. Noboru Mizushima
2
RCB2711 Atg5^(-/-)MEF Dr. Noboru Mizushima
2
RCB3706 Atg7 +/+ MEFs Dr. Komatsu Masaaki
3
RCB3707 Atg7 -/- MEFs Dr. Komatsu Masaaki
3
RCB3708 Atg3 +/+ MEFs Dr. Komatsu Masaaki
3
RCB3709 Atg3 -/- MEFs Dr. Komatsu Masaaki
3

References
[1]The 2016 Nobel Prize in Physiology or Medicine
[2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004. PMID: 15525940
[3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005. PMID: 15866887

Other Resources(Riken BRC)
Experimental Animal Division
Gene Engineering Division



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