The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular cells to investigate the role of autophagy in the cell lines. [2,3].
List of cell lines
| Cell No. | Cell Name | Depositor | References |
|---|---|---|---|
| RCB2710 | Atg5^(+/+)MEF | Dr. Noboru Mizushima | |
| RCB2711 | Atg5^(-/-)MEF | Dr. Noboru Mizushima | |
| RCB3706 | Atg7 +/+ MEFs | Dr. Komatsu Masaaki | |
| RCB3707 | Atg7 -/- MEFs | Dr. Komatsu Masaaki | |
| RCB3708 | Atg3 +/+ MEFs | Dr. Komatsu Masaaki | |
| RCB3709 | Atg3 -/- MEFs | Dr. Komatsu Masaaki |
References
[1]The 2016 Nobel Prize in Physiology or Medicine
[2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004. PMID: 15525940
[3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005. PMID: 15866887
Other Resources(Riken BRC)
Experimental Animal Division
Gene Engineering Division