{"id":9918,"date":"2016-10-06T15:06:32","date_gmt":"2016-10-06T06:06:32","guid":{"rendered":"http:\/\/cell.brc.riken.jp\/ja\/?page_id=9918"},"modified":"2020-12-17T15:39:28","modified_gmt":"2020-12-17T06:39:28","slug":"nobel_prize_2016","status":"publish","type":"page","link":"http:\/\/cell.brc.riken.jp\/ja\/nobel_prize_2016","title":{"rendered":"\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7814\u7a76\u306b\u6709\u7528\u306a\u7d30\u80de\u682a"},"content":{"rendered":"

2016\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u30fb\u751f\u7406\u5b66\u8cde\u306f\u3001\u300c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u300d\u3067\u5927\u9685\u826f\u5178\u5148\u751f\uff08\u6771\u4eac\u5de5\u696d\u5927\u5b66\u6804\u8a89\u6559\u6388\uff09\u304c\u53d7\u8cde\u3055\u308c\u307e\u3057\u305f[1]\u3002
\n\u7406\u7814BRC\u306b\u306f\u6c34\u5cf6\u6607\u5148\u751f\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u6559\u6388\uff09\u306a\u3089\u3073\u306b\u5c0f\u677e\u96c5\u660e\u5148\u751f\uff08\u65b0\u6f5f\u5927\u5b66\u5927\u5b66\u9662\u6559\u6388\uff09\u304c\u5927\u9685\u826f\u5178\u5148\u751f\u3068\u306e\u5171\u8457[2, 3]\u306b\u3088\u308a\u3054\u767a\u8868\u3055\u308c\u305f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7814\u7a76\u306b\u6709\u7528\u306a\u7d30\u80de\u682a\u304c\u5bc4\u8a17\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u7686\u69d8\u306e\u3054\u5229\u7528\u3092\u304a\u5f85\u3061\u3044\u305f\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n

\u4fdd\u6709\u30ea\u30bd\u30fc\u30b9\u30ea\u30b9\u30c8<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
\u7d30\u80de\u756a\u53f7<\/th>\n\u7d30\u80de\u540d<\/th>\n\u5bc4\u8a17\u8005<\/th>\n\u6587\u732e<\/th>\n\u5229\u7528\u8005\u6587\u732e<\/th>\n<\/tr>\n
RCB2710<\/a><\/td>\nAtg5^(+\/+)MEF<\/td>\n\u6c34\u5cf6\u6607\u5148\u751f<\/td>\n
2<\/center><\/td>\n
22<\/center><\/td>\n<\/tr>\n
RCB2711<\/a><\/td>\nAtg5^(-\/-)MEF<\/td>\n\u6c34\u5cf6\u6607\u5148\u751f<\/td>\n
2<\/center><\/td>\n<\/tr>\n
RCB3706<\/a><\/td>\nAtg7 +\/+ MEFs<\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n
3<\/center><\/td>\n
<\/center><\/td>\n<\/tr>\n
RCB3707<\/a><\/td>\nAtg7 -\/- MEFs<\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n
3<\/center><\/td>\n<\/tr>\n
RCB3708<\/a><\/td>\nAtg3 +\/+ MEFs<\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n
3<\/center><\/td>\n
<\/center><\/td>\n<\/tr>\n
RCB3709<\/a><\/td>\nAtg3 -\/- MEFs<\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n
3<\/center><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6587\u732e<\/strong>
\n[1]The 2016 Nobel Prize in Physiology or Medicine<\/a>
\n[2]\tKuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032\u20131036, 2004.\u3000PMID: 15525940<\/a>
\n[3]\tKomatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005.\u3000PMID: 15866887<\/a><\/p>\n

\u5229\u7528\u8005\u6587\u732e<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Title<\/th>\nPubMedID<\/th>\n<\/tr>\n
Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection.<\/td>\n25091564<\/a><\/td>\n<\/tr>\n
Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation.<\/td>\n24130786<\/a><\/td>\n<\/tr>\n
Delphinidin Induces Autolysosome as well as Autophagosome Formation and Delphinidin-Induced Autophagy Exerts a Cell Protective Role.<\/td>\n23129091<\/a><\/td>\n<\/tr>\n
H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition.<\/td>\n23810683<\/a><\/td>\n<\/tr>\n
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus.<\/td>\n23006589<\/a><\/td>\n<\/tr>\n
Sucrose induces vesicle accumulation and autophagy.<\/td>\n25389129<\/a><\/td>\n<\/tr>\n
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy.<\/td>\n25179110<\/a><\/td>\n<\/tr>\n
Induction of Interferon-Stimulated Genes by Chlamydia pneumoniae in Fibroblasts Is Mediated by Intracellular Nucleotide-Sensing Receptors.<\/td>\n20386592<\/a><\/td>\n<\/tr>\n
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.<\/td>\n22982048<\/a><\/td>\n<\/tr>\n
Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes A\u03b2 Generation.<\/td>\n21289194<\/a><\/td>\n<\/tr>\n
Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein.<\/td>\n26957541<\/a><\/td>\n<\/tr>\n
Autophagosomal IB Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor–induced Nuclear Factor-B (NF-B)Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.<\/td>\n <\/td>\n
Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.(NF-\u03baB) Activity.<\/td>\n21454695<\/a><\/td>\n<\/tr>\n
Plasma cells require autophagy for sustainable immunoglobulin production.<\/td>\n23354484<\/a><\/td>\n<\/tr>\n
A novel quantitative flow cytometry-based assay for autophagy.<\/td>\n20458170<\/a><\/td>\n<\/tr>\n
Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins.<\/td>\n22438538<\/a><\/td>\n<\/tr>\n
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.<\/td>\n21368103<\/a><\/td>\n<\/tr>\n
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1\/p62.<\/td>\n21536669<\/a><\/td>\n<\/tr>\n
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62\/SQSTM1.<\/td>\n21536669<\/a><\/td>\n<\/tr>\n
Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2\u03b1.<\/td>\n24648524<\/a><\/td>\n<\/tr>\n
Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells.<\/td>\n23452544<\/a><\/td>\n<\/tr>\n
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates.Renal Ischemia-Reperfusion Injury<\/td>\n26444017<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u305d\u306e\u4ed6\u7406\u7814BRC\u304c\u4fdd\u6709\u3059\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u30ea\u30bd\u30fc\u30b9<\/strong><\/p>\n