{"id":9206,"date":"2016-10-06T15:09:34","date_gmt":"2016-10-06T06:09:34","guid":{"rendered":"http:\/\/cell.brc.riken.jp\/en\/?page_id=9206"},"modified":"2016-10-06T15:49:13","modified_gmt":"2016-10-06T06:49:13","slug":"nobel_prize_2016","status":"publish","type":"page","link":"http:\/\/cell.brc.riken.jp\/en\/nobel_prize_2016","title":{"rendered":"Research tools to investigate the role of autophagy in the cell lines"},"content":{"rendered":"

The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi \u201cfor his discoveries of mechanisms for autophagy\u201d [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular cells to investigate the role of autophagy in the cell lines. [2,3]. <\/p>\n

List of cell lines<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Cell No.<\/th>\nCell Name<\/th>\nDepositor<\/th>\nReferences<\/th>\n<\/tr>\n
RCB2710<\/a><\/td>\nAtg5^(+\/+)MEF<\/td>\nDr. Noboru Mizushima<\/td>\n
2<\/center><\/td>\n<\/tr>\n
RCB2711<\/a><\/td>\nAtg5^(-\/-)MEF<\/td>\nDr. Noboru Mizushima<\/td>\n
2<\/center><\/td>\n<\/tr>\n
RCB3706<\/a><\/td>\nAtg7 +\/+ MEFs<\/td>\nDr. Komatsu Masaaki<\/td>\n
3<\/center><\/td>\n<\/tr>\n
RCB3707<\/a><\/td>\nAtg7 -\/- MEFs<\/td>\nDr. Komatsu Masaaki<\/td>\n
3<\/center><\/td>\n<\/tr>\n
RCB3708<\/a><\/td>\nAtg3 +\/+ MEFs<\/td>\nDr. Komatsu Masaaki<\/td>\n
3<\/center><\/td>\n<\/tr>\n
RCB3709<\/a><\/td>\nAtg3 -\/- MEFs<\/td>\nDr. Komatsu Masaaki<\/td>\n
3<\/center><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/strong>
\n[1]The 2016 Nobel Prize in Physiology or Medicine<\/a>
\n[2]\tKuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032\u20131036, 2004.\u3000PMID: 15525940<\/a>
\n[3]\tKomatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005.\u3000PMID: 15866887<\/a><\/p>\n

Other Resources(Riken BRC)<\/strong>
\nExperimental Animal Division<\/a>
\nGene Engineering Division<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi \u201cfor his discoveries of mechanisms for autophagy\u201d [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular cells to investigate the role of autophagy in the cell lines. [2,3]. List of cell lines Cell No. Cell Name Depositor References RCB2710 Atg5^(+\/+)MEF Dr. Noboru Mizushima 2 RCB2711 Atg5^(-\/-)MEF Dr. Noboru Mizushima 2 RCB3706 Atg7 +\/+ MEFs Dr. Komatsu Masaaki 3 RCB3707 Atg7 -\/- MEFs Dr. Komatsu Masaaki 3 RCB3708 Atg3 +\/+ MEFs Dr. Komatsu Masaaki 3 RCB3709 Atg3 -\/- MEFs Dr. Komatsu Masaaki 3 References [1]The 2016 Nobel Prize in Physiology or Medicine [2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032\u20131036, 2004.\u3000PMID: 15525940 [3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005.\u3000PMID: 15866887 Other Resources(Riken BRC) Experimental Animal Division Gene Engineering Division<\/p>\n","protected":false},"author":15,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-9206","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/9206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/comments?post=9206"}],"version-history":[{"count":4,"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/9206\/revisions"}],"predecessor-version":[{"id":9212,"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/9206\/revisions\/9212"}],"wp:attachment":[{"href":"http:\/\/cell.brc.riken.jp\/en\/wp-json\/wp\/v2\/media?parent=9206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}