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オートファジー研究に有用な細胞株


2016年のノーベル医学・生理学賞は、「オートファジーの仕組みの解明」で大隅良典先生(東京工業大学栄誉教授)が受賞されました[1]。
理研BRCには水島昇先生(東京大学大学院教授)ならびに小松雅明先生(新潟大学大学院教授)が大隅良典先生との共著[2, 3]によりご発表されたオートファジー研究に有用な細胞株が寄託されています。
皆様のご利用をお待ちいたしております。

保有リソースリスト

細胞番号 細胞名 寄託者 文献 利用者文献
RCB2710 Atg5^(+/+)MEF 水島昇先生
2
22
RCB2711 Atg5^(-/-)MEF 水島昇先生
2
RCB3706 Atg7 +/+ MEFs 小松雅明先生
3
RCB3707 Atg7 -/- MEFs 小松雅明先生
3
RCB3708 Atg3 +/+ MEFs 小松雅明先生
3
RCB3709 Atg3 -/- MEFs 小松雅明先生
3

文献
[1]The 2016 Nobel Prize in Physiology or Medicine
[2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004. PMID: 15525940
[3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005. PMID: 15866887

利用者文献

Title PubMedID
Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection. 25091564
Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation. 24130786
Delphinidin Induces Autolysosome as well as Autophagosome Formation and Delphinidin-Induced Autophagy Exerts a Cell Protective Role. 23129091
H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition. 23810683
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus. 23006589
Sucrose induces vesicle accumulation and autophagy. 25389129
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. 25179110
Induction of Interferon-Stimulated Genes by Chlamydia pneumoniae in Fibroblasts Is Mediated by Intracellular Nucleotide-Sensing Receptors. 20386592
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. 22982048
Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation. 21289194
Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein. 26957541
Autophagosomal IB Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor–induced Nuclear Factor-B (NF-B)Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.  
Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.(NF-κB) Activity. 21454695
Plasma cells require autophagy for sustainable immunoglobulin production. 23354484
A novel quantitative flow cytometry-based assay for autophagy. 20458170
Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins. 22438538
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. 21368103
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. 21536669
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1. 21536669
Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α. 24648524
Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells. 23452544
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates.Renal Ischemia-Reperfusion Injury 26444017

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