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Research tools to investigate the role of autophagy in the cell lines

The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular cells to investigate the role of autophagy in the cell lines. [2,3].

List of cell lines

Cell No. Cell Name Depositor References
RCB2710 Atg5^(+/+)MEF Dr. Noboru Mizushima
2
RCB2711 Atg5^(-/-)MEF Dr. Noboru Mizushima
2
RCB3706 Atg7 +/+ MEFs Dr. Komatsu Masaaki
3
RCB3707 Atg7 -/- MEFs Dr. Komatsu Masaaki
3
RCB3708 Atg3 +/+ MEFs Dr. Komatsu Masaaki
3
RCB3709 Atg3 -/- MEFs Dr. Komatsu Masaaki
3

References
[1]The 2016 Nobel Prize in Physiology or Medicine
[2] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004. PMID: 15525940
[3] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005. PMID: 15866887

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Experimental Animal Division
Gene Engineering Division